Oilesen Presentation
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Vitamin D and Covid-19

The world is now experiencing its third major epidemic of coronavirus (CoV) infections began in Wuhan, Hubei, China, in late 2019 and named COVID-19. After an initial explosive outbreak of pneumonia of unknown etiology in China, the disease spread first to neighboring Asian countries and then worldwide. Patients with COVID-19 presented with a constellation of symptoms such as fever, dry cough, dyspnea, sore throat, and nasal congestion and radiological findings showed bilateral lung glassy opacities. Vitamin D has many mechanisms by which it reduces the risk of microbial infection and death, including physical barrier, cellular natural immunity, and adaptive immunity. Vitamin D supplementation has shown favorable effects in viral infections including influenza and HIV. The effects of vitamin D supplementation during covid 19 infection remain controversial. Looking ahead, clinical studies are needed to define better cut offs for vitamin D levels and, finally, which dosage is the best.


Key points

Vitamin D reduces the risk of microbial infection and death.

  • Vitamin D supplementation has shown favorable effects in viral infections including influenza and HIV.
  • Vitamin D is a negative endocrine renin-angiotensin system (RAS) modulator.
  • Vitamin D increases expression and concentration of ACE2 and has a potential protective role against acute lung injury/acute respiratory distress syndrome.
  • Despite the potential effectiveness of vitamin D as an antiviral, more solid data are needed to support this claim.
Valentis Life Sciences